Abstract: Integrated system validation(ISV) is the performance-based assessment of integrated human-system interface (HIS)is prior to loading in nuclear power plants. Appropriate integrated system validation scenario selection method is to confirm that the activity is sufficient, necessary and orderly. Based on the HSI design of nuclear power plants, this paper proposes a set of systematic and implementable integrated system validation scenario selection method  meeting the review requirements of Human Factors Engineering Program Review Model(NUREG 0711)on sampling of operational conditions, so that the integrated system validation work can be more reasonable and efficient.