Abstract: In order to improve the safety and reliability of the personnel airlock of nuclear power plants, this paper develops a digital prototype of personnel airlock and its key components. In addition, combined with structural reliability analysis with digital prototype simulation, the weak links that influence the reliability of the equipment are specifically analyzed. By the failure mode and effect analysis (FMEA) method, the weak links of the equipment are found. Weak link-lifting mechanism is analyzed by using dynamics simulation software ADAMS. And the finite element analysis carried out by ANSYS output the stress distribution and the deformation of these components in accident condition. The results show that the rationality of the structural design of personnel airlock and the correctness of the assembly relationship are verified.