Abstract: Unit 1 and unit 2 of Hainan Nuclear Power Plant adopt CNP650 reactor developed on self-reliance. Because of the obvious peak and valley period of the power consumption in Hainan power grid, the key to transition from annual refueling to long cycle is the great differences of the cycle length between the long and the short cycles. For these purposes, this paper completed the design of new fuel assembly types and enrichment, new fuel assembly number and layout, and the independent transition cycle, and then obtained the fuel management strategy of CNP650 rector. This strategy is composed of the alternative long and short equilibrium cycles, starting from the 5th cycle, through 4 transition cycles, into the equilibrium cycle. The equilibrium cycle are composed of 2 cycles which length are 517.3EFPD and 464.0EFPD. All the parameters meet the design requirements of the long fuel cycle management. This fuel management strategy effectively solves the specific requirements of Hainan Nuclear Power Plant, and can be directly used for the operation of Hainan Nuclear Power Plant.