Abstract: In order to protect the workers in the spent fuel storage compartment from internal radiation, the airborne radioactive concentration in the spent fuel storage compartment needs to be controlled. Exhaustion of the airborne radiation is mainly realized through the ventilation system. According to the characteristics of the spent fuel storage tank, four ventilation methods are designed in this paper. Airpak software is used to simulate the four ventilation methods of the spent fuel storage tank. By comparing and analyzing the polluted steam concentration field, flow field and polluted steam trajectory, the effects of four ventilation methods on the airborne radioactive exclusion are studied. The results show that the layered air supply method Ⅱ has a better effect on the airborne radioactive emissions, and under this ventilation mode, the airborne radioactive concentration on the personnel working platform is lower than that in other three ventilation modes.