Abstract: Based on the analysis of the problems resulting from the tool limitations during the radiation shielding design of M310 nuclear power plant and the requirements presented by the radiation shielding design of HPR1000 nuclear power plant, the requirements for Monte Carlo(MC) method during the optimization design of the radiation shielding for advanced PWR nuclear power plant are presented from four aspects, which are the software interface, input interface, dose rate calculation function and radiation field application expansion. The radiation shielding optimization design practice based on MC method in HPR1000 nuclear power plant shows that, by the development of the software interface, input interfaces and radiation field application expansion, the calculation code based on MC method can play a key role in the radiation shielding optimization design of advanced PWR nuclear power plant, and significantly improve the radiation shielding optimization design of PWR nuclear power plant.