Abstract: The heat exchange tube bundle is an important part of the steam generator, and its reliability directly affects the safe operation of the nuclear power plant reactor. Based on the research in related fields, a computational fluid dynamics(CFD)/computational structural dynamics(CSD) coupling calculation method with higher accuracy is proposed and developed, and the numerical simulation research is carried out on the coupling vibration phenomenon between adjacent tube bundles. The vortex structure of the tube array and the vibration response law between adjacent tube bundles are analyzed in the time domain and frequency domain. The research results show that the vortex is generated and shed in the upstream of the tube bundle, and then gradually develops downstream. The interaction of a large number of shedding vortices between the tube bundles greatly enriches the vortex frequency in the flow field, and the vibration of the tube bundle is affected by the natural frequency and the vortex frequency of the tube bundle. The vibration of the surrounding adjacent tube bundles will have a significant impact on the fluid force fluctuation and frequency dominance of the tube bundle, and weaken the lift fluctuation to a certain extent, and when the adjacent vibrating tube bundles are in the same row, the impact on the vibration displacement of the tube bundle is more significant.