Abstract: In order to compensate for the defects of event-oriented emergency procedure (EOP) and state-oriented emergency procedure (SOP), HPR1000 nuclear power technology takes the advantages of the two operation procedures. Considering probabilistic safety analysis (PSA),  a new symptom based emergency operating procedures (SEOP) through a large number of operation analysis supporting calculations is established. As an example, the operator actions during steam line break accident guided by SEOP is studied and compared with EOP and SOP. The results show that SEOP can deal with the accident rapidly and directly and can defend multi-accidents. The accident identification and mitigation measures are reasonable and effective. It can make full use of HPR1000 active and passive safety systems to deal with accidents, give full play to the design advantages of the safety system, and enhance the safety level of HPR1000. The principle, methodology and technique of the development can be used in the procedure development for the similar plant and can be used as a reference to improve the procedures for nuclear power plants in service.