Abstract: The whole modular hoisting of concrete slab is a major hoisting project for construction of nuclear power plants. Concerning the actual situation that the geometric center of concrete slab modules in nuclear power plants are deviated from gravity, a specific hoisting connection system is designed considering present hoisting points, which used welded H-beam lifting frame and a series of research is accomplished, which contained calculating the bary centre of concrete base module, establishing the mathematical model with ANSYS software to analyze the stress and displacement of the hoisting frame, hanging ears and pin wheel. The results show that the H-beam welding lifting frame structure is reliable and the lifting parameter design is reasonable. The overall hoisting task is completed by using mobile cranes, hydraulic jacking towers, hoisting beams, connecting hoisting frames, Loxic-leveling and other complex processes.