Abstract: The major function, action and flow chart of chemical management system for a nuclear power plant is introduced in detail, and its application in the world is illustrated. Referring to years of experience in the development of the chemical data management system in nuclear power plants, this paper discusses how to achieve the purpose of rapid identification and diagnosis by the application of artificial intelligence technology and chemical anomaly data, to meet the needs of plant operation, achieve the aim of safe, reliable and economical operation of nuclear power plants.