Abstract: Seismic safety has always been an important aspect of nuclear safety, while base seismic-isolation technology is an effective means to improve seismic safety of nuclear facilities. This paper, taking China’s mega kilowatt pressurized reactor as an example, provides the overall seismic isolation solution of nuclear island as well as the analysis of the isolation effects from the angle of design standardization of nuclear power station. Meanwhile, combined with the engineering application, major problems and solutions facing the nuclear power engineering in scale-applying seismic isolation technology are discussed in the paper. Therefore, the paper is of certain reference value and guiding significance to the application of seismic isolation technology in the field of nuclear power engineering.