Abstract: The mechanical analysis results usually cannot match the requirement of criterion or specification for new layout high-energy piping system. Then the design of the piping system or the location or function of supports on the piping should be improved until requirements of criterion and specification are matched. Then the space should be checked to insure that the piping and its supports can be laid down. Repeat improvement and harmonization are needed in order to find a satisfying piping layout. An optimization analysis method which can reduce the number of improvement and harmonization is introduced in this paper. This method is used in a new high-energy piping system mechanical analysis. The process of high-energy piping mechanical analysis, the method for special stress indices calculation and the evaluation of analysis results are also introduced in this paper. The results show that the optimization analysis method is an effective and practical method used for new high energy piping system analysis.