Abstract: When the nuclear power plants use the fuel assemblies produced from reprocessing plant, the Closed Loop of nuclear fuel cycle is realized. It can increase the fuel utilization and mitigate the spent fuel storage problems. The PC fuel is made from the fuel reprocessing products by enriching and processing. It has been used over 20 years in the Russian VVER-1000 plants. The owner has intended to use PC grade fuel from Cycle 10 of Unit 1. The research and design about VVER-1000 using TVS-2M fuel assembly made of PC uranium hexafluoride is carried out using KASKAD program package. An optimized fuel management scheme is obtained through the feasibility analysis.