Abstract: Based on the investigation and analysis of intake blockage events on the global units in service, the cause of the cooling water intake blockage is analyzed, and the corresponding experience feedbacks and improvements are put forward by strengthening the identification and analysis of initiating conditions, reinforcing the design review and change, enhancing the maintenance strategy and control, and improving the response capability. Operation status of the intake of Qinshan units are analyzed and evaluated comprehensively, and the improved methods and preventive measures are put forward to prevent the invasion of aquatic organisms such as water hyacinth and breeding of sea creatures, and strengthen the maintenance and operation management of rotating screens.