Abstract: Dynamic artificial boundary is a necessary means to using the 3D finite element technique to solve the dynamic problem of foundation. Based on the viscoelastic boundary and the transmitting boundary developed, the seismic response analysis of a building structure in a typical example of nuclear power engineering in the northeast of China is carried out, and the contrast analysis of two kinds of complex artificial foundation boundary model results with simplified homogeneous foundation model is implemented in order to explain the analysis differences based on the different methods in the simulation of dynamic effects for complex foundation.