Abstract: This paper analyzes the design of the HVAC support in EPR NPP. Compared with the M310 NPP, the EPR NPP improves the support structure. Statics mechanics formula and ANSYS software are used to calculate the space between two supports. RSTAB software is used to calculate the strength of the profile and define the size of the profile and bolt. Based on the analysis, the standard support structure and distances between the supports of the EPR NPP is defined, and the support steel specification and loads is listed.