Abstract: In order to insure the quality of safety software of the digital system inside the nuclear power plant, the thorough V&V activities need to be performed on the safety software. According to the standard systems at home and abroad, establishing the V&V activity flow which satisfies the standard requirements, and performing a series of strict and complete V&V activities, is a more viable way to improve the software quality. Based on IEEE 1012-2004, this paper discussed in detail the V&V flow in the development process of safety software, and analyzed the key problems during the V&V activities, so as to provide reference to the development of V&V activities for safety software.