Abstract: The reactor control room is the most concentrated area of the human-machine interface,and also the location of most mis-operation.Improving the control room design is one of the key factors to improve the reactor safety.Based on the characteristics of the low temperature reactor,safety review is conducted according to the regulation and standards related to nuclear power plants,and making reference to the design rule and function requirements of the low temperature reactor.According to the safety review requirements,designers changed the related design of the control room for optimization,so as to improve the safety of facilities.