Abstract: Parameter sensitivity analysis of the interface force model and/or its key parameters in the momentum transfer models was carried out with the framework of two-fluid model. The effect of the interface force model and/or its key parameters on the axial and radial distribution of two-phase flow parameters in a vertical round tube under subcooled flow boiling process was studied and compared with the integrated effect experiment data. It was shown that the drag force is with effect on the axial two-phase flow process rather than the radial parameter distribution, and non-drag forces have strong effect on the radial parameter distribution rather than the axial two-phase flow process. In the aspect of non-drag forces, turbulence dispersion force and lift force have a dominant effect on the radial void fraction distribution, especially the peak value of void near the wall. Wall lubrication force mainly affects the peak value of void near the wall. Virtual mass force has little effect neither on the axial nor the radial parameter distribution and can be neglected in the simulation of subcooled boiling process in a round tube.