Abstract: Operation procedures of nuclear power plants are closely related to the operation safety of nuclear power plants.The setpoints information is an important part of operation procedure contents,and the setpoints determination is very difficult in operation procedure development.The operation procedure system and setpoint contents are analyzed for advanced passive plant of demonstration project,and the functions and the structures of setpoints are also analyzed following the requirement of nuclear safety regulations.A systematical approach is provided for setpoints determination,and it is meaningful for the independent operation procedure development of advanced passive plants,as well as the operation safety of plants.