Abstract: Taking a pressurized water nuclear power plant as an example, this research uses CORA code to analyze the effect of material construction, the cobalt content of steam generator tubes, purification efficiency, core power and the concentration of Li OH on the corrosion production of 58 Co and 60 Co in the primary circuit. The results show that these factors can effectively reduce the activity concentration of activated corrosion products sources terms through the control of cobalt content of the steam generator tubes, increasing the concentration of Li OH, improving the coolant purification efficiency and reducing the power level. The research can provide guidance for the radiation dose control of nuclear power plants.