Abstract: Advanced analysis methods for prediction and reduction of vibration and noise are of great significance for reducing vibration noise level of the structure. In order to make accurate noise prediction, it is necessary to adopt the appropriate method and establish the model of noise prediction. Firstly, the variable parameters and their influence law of vibration noise prediction and analysis method, for reactor and the primary loop system, are studied. Comparative studies are made on the acoustic analysis methods including direct boundary element method, acoustic finite element automatic matching layer method, acoustic finite element method adaptive order, and acoustic finite element automatic matching layer method combined acoustic finite element method adaptive order. Secondly, the effect of pressure hull on the vibration noise is studied by the finite element method and the acoustic boundary element method. Meanwhile, the effect of reinforcing rib and double shell on the system vibration characteristics and radiated noise is obtained. Based on these studies, a vibration-acoustic model is established. Then, the research of vibration reduction evaluation, acoustic radiation analysis, vibration and noise reduction are carried out. The vibration level difference of typical transfer path, the sound pressure level and the external acoustic field radiated by the pressure hull, and the effect of vibration and noise reduction with different vibration reduction measures are obtained.