Abstract: Using the loose part monitoring system (LPMS) developed by NPIC, the development of 16 channel LPMS software is carried out based on localized PXI (PCI extensions for instrumentation) modules. This paper introduces the software design requirements, design principles, design process and the design of the main interface, and the software implementation of the interface program of localized PXI control module is described in detail. The successful development of LPMS software based on localized PXI modules meets the design requirements, and it has been successfully applied in LPMS of a nuclear power plant abroad, which has played an active role in ensuring the safe and economical operation of the nuclear power plant.