Abstract: In order to solve the problems of how to share the information from the standardization of safety production how to improve the working efficiency, and how to statistically analyze a large amount of data from standardization of safety production in implementing the standardization of safety production for the operating nuclear power plants in China, the management information system for the standardization of safety production for an operating nuclear power plant was designed. The application results show that the management information system for the standardization of safety production for an operating nuclear power plant helped to increase the information transmission among departments and share the information from standardization of safety production, to optimize the management process and increase the working efficiency for standardization of safety production, and to statistically analyze a large amount of data from standardization of safety production in an operating nuclear power plant.