Abstract: There has been a severe problem of hydrophobic pipeline vibration in the pipeline of High-pressure heater to the deaerator since the commissioning of Fujian Fuqing Nuclear Power Plant Unit 2. The unit was forced to decrease the power due to the pipe vibration, which has a serious impact on the stable operation of power plant equipment and the economic benefits of power plant. This paper introduces the vibration phenomena of the pipeline in detail and analyzes the causes of vibration from the aspects of system parameters change, equipment structure and the installation of field equipment. Finally, the abnormal vibration of high-altitude deaerator pipeline can be eliminated by pertinent measures, which can ensure the long-term safe operation of pipeline system. The results can be used for reference in dealing with the vibration of pipes of similar units.