Abstract: For the requirements of the reactor hydraulic analysis, the PHYCA program has been developed by Nuclear Power Institute of China on self-reliance. In order to evaluate its engineering adaptability, the analysis of the reactor hydraulics of HPR1000 was performed based on PHYCA. Pressure drop in the reactor vessel, bypass flow and hydraulic load of the reactor internals were calculated. The results of PHYCA have good agreement with the engineering design values. It demonstrates that PHYCA is suitable for the analysis of the reactor hydraulics of similar nuclear power plants.