Abstract: In order to realize the small batch application of third generation China fuel assembly (CF3), the fuel management strategy of the cycle 4 to cycle 7 of the unit 2 of Fangjiashan NPP is studied in this paper. Based on the consideration of the economy, the safety of nuclear power plant operation and the irradiation test requirement of small batch application of CF3 fuel assembly, the fuel management scheme for the small batch irradiation of CF3 fuel assembly is established. In order to further improve the maximum discharging burnup of CF3 fuel assembly, the feasibility of 55000 MW·d/t(U) for CF3 fuel assembly burnup is analyzed. The research shows that the fuel management scheme for the small batch irradiation of CF3 fuel assembly meets the requirement of the safety and economy of nuclear power plant operation, and satisfies the irradiation test requirement of small batch application of CF3 fuel assembly. If the core loading scheme of the third cycle of the fuel management scheme is properly adjusted later, the burnup of 55000 MW·d/t(U) for CF3 fuel assemblies can be achieved.