Abstract: The determination methods for oxygen and nitrogen in uranium-silicon compound were studied by oxygen/nitrogen analyzer. The contents of oxygen and nitrogen in uranium-silicon compounds were determined by infrared absorption method and thermal conductivity method, respectively. The effects of sampling amount, flux, heating power and analysis time on the determination of oxygen and nitrogen were investigated, and the related working parameters were optimized. When the sample dose is 0.10 g (accurate to 0.0001 g), under the condition of using nickel basket as the flux additive and 4200 W heating power, the determination range of oxygen is 0.00050%-0.365%, and the determination range of nitrogen is 0.00050%-0.026%. The linear correlation coefficients are greater than 0.999, and the relative standard deviations are better than 10%.