Abstract: During the power operation of PWR, due to burnup effect and boronation effect, the abundance of ¹⁰B in the primary circuit boric acid solution will change continuously with time, and the nuclear power plant can not provide the real-time measured value of ¹⁰B abundance. As a result, the calculated value of the critical boron concentration in the nuclear design program is lower than the measured value in the middle of the cycle. Therefore, in order to reduce the deviation between the calculated value and the measured value of the critical boron concentration in the primary circuit of the core, this paper gives a calculation method of ¹⁰B abundance based on the Bamboo-C software independently developed by the Nuclear Engineering Computational Physics (NECP) Laboratory of Xi'an Jiaotong University. This method can consider the influence of burnup effect and boronation effect on the critical boron concentration at the same time. Using the ¹⁰B abundance calculation method mentioned in this paper, the power operation history of the M310 unit of Fuqing NPP was tracked and simulated, and the calculated values of the primary circuit critical boron concentration and B-10 abundance were compared and verified with the measured values. The verification results show that the ¹⁰B abundance calculation method mentioned in this paper can improve the numerical calculation results of core critical boron concentration, and has the conditions for industrial application.