Loop System Debugging for Production of 125I by Continuous Cycle Reactor Irradiation
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摘要: 采用连续循环法辐照生产医用同位素125I，不仅能实现靶料循环辐照，同时产生的125I被碘吸附装置所捕集提取。125I制备工艺装置系统根据岷江泳池试验堆（MJTR）场地布局已完成现场安装，本研究对该系统的工艺设计构思、功能组成、研发进展等进行了详细的论述，同时采用对回路保压、循环辐照过程模拟等方法对整个系统装置的气密性、功能性以及稳定性等开展详细的调试验证。结果表明，整个系统装置具有较好的气密性，其设备的功能性以及稳定性均满足技术设计要求，该调试结果为后续热试验研究奠定了基础。Abstract: The production of medical isotope 125I by continuous cycle irradiation can not only realize the cycle irradiation of the target material, but also the 125I produced will be captured by the iodine adsorption device. The 125I preparation process device system had been installed on site according to the site layout of Minjiang test reactor (MJTR). In this study, the process design concept, functional composition and research and development progress of the system are discussed in detail. Meanwhile, the air tightness, functionality and stability of the whole system device were debugged and verified by using the pressure maintaining of the loop and the simulation of the cycle irradiation process. The results show that the whole system device has good air tightness, and the functionality and stability of the equipment meet the technical design requirements. The research results lay a foundation for the follow-up thermal test research.
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Key words:
- Continuous circulation method /
- Reactor irradiation /
- 125I /
- System debugging
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图 1 连续循环辐照制备125I的工艺流程图
Figure 1. Process Flow Chart of 125I Preparation by Continuous Cycle Irradiation
图 2 回路抽负压及检漏调试流程图
Figure 2. Debugging Flow Chart of Loop Negative Pressure and Leak Detection
图 5 主回路保压24 h后主回路压力变化图
Figure 5. Pressure Variation of the Main Loop after Pressure Held for 24 Hours
图 6 气体转移与循环辐照系统调试流程图
Figure 6. Debugging Flow Chart of Gas Transfer and Cycle Irradiation System
图 7 主回路循环流量与压力随时间变化关系图
Figure 7. Relationship between Gas Flow and Pressure of Main Loop Circulation with Time
表 1 主回路保压24 h后主回路压力理论值与实际值对比
Table 1. Comparison between Theoretical Values and Actual Values of Main Loop after Pressure Held for 24 Hours
运行过程 开始保压实
测值（28.8℃）保压24 h后（27.4℃） 实际压
力增加值实测值 理论计算值 主回路压力/kPa 302.1 301.5 300.7 0.8 
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表 2 主回路气体模拟循环辐照全过程压力变化
Table 2. Pressure Change of Whole Process of Main Loop Gas Simulation Cycle Irradiation
运行过程 开始保压
实测值
（26.5℃）循环11 h后
（28.7℃）实
测值保压22 h后（26.9℃） 实际压力
增加值实测值 理论计算值 主回路压
力/kPa103.5 37.4 103.6 103.6 0
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表 3 各储气罐保压24 h后压力对比数据表
Table 3. Comparison of Pressures after 24 Hours of Pressure Holding for Gas Storage Tanks
运行过程 开始保压实测值
（26.4℃）保压24 h（26.8℃） 实际压力
增加值实测值 理论计算值 1#储气罐压力/kPa 416.3 417.6 416.9 0.7 2#储气罐压力/kPa 413.5 415.1 414.1 1.0 3#储气罐压力/kPa 413.8 415.3 414.4 0.9
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[1] HU P, HUANG J W, ZHANG Y L, et al. Iodine-125 seed implantation in the treatment of malignant tumors[J]. Journal of Interventional Medicine, 2023, 6(3): 111-115. doi: 10.1016/j.jimed.2023.07.006 [2] RUSSELL H T. Production of 125I and fabrication 125I X-ray sources: ORNL-TM-562[R]. Oak Ridge: Oak Ridge National Laboratory, 1963. [3] 葛巨龙. 125I的生产现状与前景展望[J]. 同位素,2013, 26(4): 204-207. doi: 10.7538/tws.2013.26.04.0204 [4] HASSAL S B. Method and apparatus for production of radioactive iodine: US, 6056929A[P]. 2000-05-02. [5] 于宁文,沈亦佳,吴宇轩,等. 制备125I的堆照循环回路模拟系统调试[J]. 同位素,2018, 31(2): 104-109. doi: 10.7538/tws.2017.youxian.042 [6] 李波,罗宁,曾俊杰,等. 125I生产工艺研究进展与展望[J]. 同位素,2020, 33(6): 366-373. doi: 10.7538/tws.2019.youxian.071 -
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