The DRM methodology uses the response surface method for uncertainty analysis, and introduces a penalization mode that covers the overall calculation uncertainty, which enables estimation of PCT with a confidence level greater than 95%. In this paper, taking the PCT as the target parameter, the nonparametric statistical method was used instead of the response surface method to perform uncertainty analysis in LB-LOCA accident. It was found that, the PCT of 95%/95% level based on nonparametric statistical method was enveloped by that based on DRM methodology.