The work of piping layout in the nuclear islands of nuclear power stations includes the pipe and the support designing, which shall satisfy the requirementss of system, vibration, weight and flexibility. This paper have introduced the routing verification program during the basic design in TAISHAN project. The program is implemented in the whole design process, and the result shows that this program can effectively verify the mechanics of the layout of process pipelines, ensure the design quality, reduce the iterative work and improve the efficiency.