The noise source identification, qualification and recognition of transmission path are the precondition of the vibration and noise control. In order to meet the engineering requirement of quantitative vibration contribution analysis, the transmission path analysis method was applied to the vibration transmission analysis of the pipe system for nuclear reactor system. By measuring the frequency response function(FRF) of each vibration transmission path, the vibration velocity of exciting points and evaluation points, and estimating the exciting forces, the TPA was performed and the vibration contribution of the facilities and pipes to the evaluation points were obtained. The experiment on a typical pipe system was used to verify the accuracy of proposed method.