To complete the production of radioisotope
63Ni based on self-reliance, the reactor physical calculation program is used to establish a balanced core model of HFETR. The process of irradiating natural nickel and high-purity
62Ni to produce
63Ni at four typical in-pile locations is simulated. The results show that high purity
62Ni is the most suitable target material. The central channel of K14 fuel element is the best irradiation position. The high specific activity
63Ni (≥5.55×10
11 Bq/g) is produced by high purity
62Ni target with irradiation time about 60 cycles; The radioactive isotope
63Ni produced by irradiation has low impurity nuclide content; The target at K14 position during the irradiation has the highest heat release rate of 9.73 W/g. Furthermore, a continuous batch production plan for segmented loading and segmentation is proposed, which can provide technical support for the subsequent engineering production line design.