The methodology for Large Break Loss of Coolant Accident(LBLOCA) licensing analysis with conservative Appendix K models plus statistical plant parameters analysis is presented in this paper.With the Appendix K version of RELAP5,which has been modified in compliance with the requirements of 10CFR50 Appendix K evaluation model,the quantification of the effect of plant status uncertainty on the safety parameter is carried out,based on a non-parametric statistical method.To demonstrate the new LOCA methodology,the LOFT L2-5 double-ended cold leg guillotine large break loss of coolant accident integral test is analyzed.It is revealed that this deterministic-realistic hybrid methodology can provide more PCT margin than the traditional Appendix K LOCA analysis by 88.7 K.