The calculation scale of fluid-structure coupling is so huge that it was rarely used in engineering.A potential-based fluid formulation is used in this paper.The formulation connects the coupling terms of the fluid-structure characteristic value equation,so nonlinear continuous equation of liquid flowing is simplified to linear elliptic equation.In this way,the calculation scale was reduced to a great extent.It was verified in many examples that the formulation is very efficient to solve the dynamic problem of liquid storage container,which can be used in nuclear reactor engineering.