Abstract: In this paper, based on the experimental results of power spectrum density of wall pressure fluctuations, the response of pipe vibration caused by orifice plate was calculated with random vibration analysis function of ANSYS code. The effect of correlation between wall pressure fluctuations on the response of pipe vibration was discussed.Furthermore, a simplified method was given, and the calculation result was compared with that of the detailed calculation. It was shown that the simplified method was convenient and efficient. The response of the pipe flow-induced vibration calculated with simplified method was conservative, so it can be used in the engineering evaluation.