Abstract: The whole process for the application of digital plant technique in the equipment transport in reactor building and the dynamic management of the spatial arrangement in Daya Bay Nuclear Power Station was introduced in the paper. The establishment of 3D digital Daya Bay plant, and the method and procedure to apply it in the nuclear power plant maintenance project have been discussed. This project utilizes the outer database to preserve the maintenance status of equipments, and avoids the damage or changing of the original 3D final model. Based on the maintenance procedure, the spatial arrangement and schedule for the maintenance of nuclear power station have simulated and optimized for the whole process. This technique can simulate and optimize the arrangement and spatial arrangement for maintenance in limited space. It has been applied successfully in the reactor vessel head replacement for Unit 2 of Daya Bay NPP to shorten the time for key routes and the total time of this project by 16 hours and 92.5 hours, respectively.