Abstract: The paper describes the research and development of shielded operation cupboard for 10^{6 252}Cf spontaneous fission neutron source. The design principle, design idea,calculation of shielding material and choice of shielding material for shielded operation cupboard are introduced. The performance for the shielded operation cupboard is measured by using low radiation intensity source. Sheiding materiral outside/inside of the shielded operation cupboard is stainless steel shell （2 mm）, polyethylene （150 mm）, and stainless steel wall （20 mm）. The effect for neutron shielding reaches 9 times, and that for Gamma ray shielding reaches near 3 times at the operation position for operator. The results show that the shielded operation cupboard meets the needs for practical operation and dose limit value requirement on the operator.