Abstract: Non-Conformity Control is very important for the successfully manufacturing of nuclear equipment. Taking the non-conformity control in the manufacturing of the nuclear island main components for Guangdong Ling’ao Nuclear Power Station (2× 1000MW PWR) by Dongfang Boiler Group Co. Ltd. as an example, this paper expounds the principles and procedures of the non-conformity control in nuclear equipment manufacturing. It can provide a reference for the concerned personnel engaged in the quality assurance in the nuclear equipment manufacturing industry in China.