Abstract: This article briefly introduces the application status, production principles, and production methods of isotopes, as well as the development overview of homogeneous solution-type reactors both domestically and internationally. It systematically elaborates on the system composition and design situation of isotope production experimental reactors, specifically including the reactor and its major systems, isotope extraction process systems, and supporting systems. Meanwhile, it provides a detailed explanation of the main technical issues related to reactor and isotopes extraction processes, such as reactivity stability, radiation protection design, prevention of fuel solution precipitation, corrosion resistance of structural materials, critical safety of fuel solutions, isotope extraction processes, uranium recovery technology, and fuel purification technology.