TVS-2M grid is an important component of TVS-2M pressurized water reactor fuel assembly which is a new upgraded product contrast with the VVER-1000.Directing at the structure characteristics with big numbers of holes and thin wall between them,we designed the technological process and fixture method.Some process difficulties have to be solved.The order of processing is optimized to solve the deformation of thin-walled structure.Edited NC macro program is adopted to solve the matter of overcutting and cutting tool broken when machining.It provides a new technology and machining method for NC machining of thin-walled plate type structure.