To improve the automation level of PWR nuclear power plant units during startup, reduce the work intensity of reactor operators, shorten the start-up time, and improve the correctness and standardization of the unit start-up, this study puts forward a control technology suitable for automatic startup of nuclear power plant, which is based on the characteristics of typical PWR nuclear power plant unit system, operation management process and control requirements of automatic startup. Based on the analysis of the applicable control range, operation breakpoints, sequence control and analog control of the automatic start-up control system of PWR, an architecture for the automatic start-up control system of nuclear power plant is established, including the architecture design, the functions and design contents of each level and the interactive interface design between levels. At the same time, a typical PWR nuclear power plant automatic start-up simulation platform is established, and the automatic start-up control system is designed by taking the start-up process of nuclear power plant operation mode Ⅲ as an example, and the proposed technical scheme is simulated and verified. The simulation results show that the automatic start-up control system design can realize the automatic start-up of nuclear power plant mode Ⅲ, reducing the operation steps and workload of operators. The designed automatic start-up control system architecture in this study can provide a reference for the application of automatic start-up control system for nuclear power plant, and is of great significance for improving the automation level of start-up process of nuclear power plant units.