Be and HR-I stainless steel was diffusion bonded by hot pressing.The microstructure,composition and phase distribution and mechanical properties of the joints were analyzed using the optical microscopy,scanning electron microscopy(SEM),scanning auger microspectroy(SAM) and x-ray diffraction(XRD),and the effect of different interlayer materials Cu and Al and Ag-Cu alloy was also discussed.The results show that it is not easy to joint Be and HR-1 stainless when Al was used as the interlayer material,but good joints can be obtained using Cu and AgCu alloy as the interlayer materials,because the formation of Be-Fe brittle intermetallic compounds was prevented.Ag-Cu alloy is the best interlayer materials among them,as it can reduce the mutual diffusion between Be and Fe.