Wavelet analysis is with the characteristics of noise reduction and multiscale resolution,and can be used to effectively extract the fault features of the typical failures of the main pumps.Simulink is used to simulate the typical faults: Misalignment Fault,Crackle Fault of rotor,and Initial Bending Fault,then the Wavelet method is used to analyze the vibration signal.The result shows that the extracted fault feature from wavelet analysis can effectively identify the fault signals.The Wavelet analysis is a practical method for the diagnosis of main coolant pump failure,and is with certain value for application and significance.