Starting with the peculiarity of helium,the differences in choosing the design parameters be-tween helium compressors and air compressors are analyzed,and the characteristics in parameter selection to increase helium compressors loading are emphasized.Because the physical characteristics of helium are quite different from that of air,the flow in helium compressors is presented as low Mach number resulting in low stage pressure ratio,so generally the variation of passage size is less in helium compressors.In order to im-prove the stage loading and decrease the stage number,it is necessary for each stage to increase reactor.A numerical study is performed for a multistage Helium compressor to analyze the flow characteristics and the redesign is carried out in this paper.