The RELAP5 itself is with the abilities to simulate nuclear power plants (NPP) control and protection systems. However, its simulation modeling are text-based, which is complicated and lacks of readability, and above all it is not suitable to model large complicated NPP control and protection systems. Simulink, which uses diagram-based modeling, however, is capable of modeling large complicated systems with high efficiency and convenience. This paper has coupled RELAP5 with Simulink, and also expanded the control and protection functions of RELAP5 with Simulink. To verify the coupling method, this paper has also compared the simulation results of the same NPP control and protection systems simulated by Simulink and RELAP5, respectively, and the comparison result has illustrated a good match between the two.