TiAlZr alloy and its thermal spraying Ni-Cr coatings are tested on the fretting wear machine and investigated comparatively at different temperatures. It is showed that when the fretting is in the gross-slip regime, temperature has great effect on the fretting wear. With temperature increasing, in the gross-slip regime, wear-resistant capability of TiAlZr titanium alloy decreases; however, that of thermal spraying Ni-Cr coatings, which is excellent particularly at 400℃ because of oxide films formation, increases. Frictional properties are improved with thermal spraying Ni-Cr coatings on TiAlZr alloy substrate.