In order to address the low convergence issue of the method of characteristics, the coarse-mesh finite difference (CMFD) formulation, which is a widely recognized acceleration technique for coarse mesh diffusion calculation, is studied to speedup the MOC transport calculation. Numerical tests on C5G7 MOX benchmark problem and a 69 group test problem defined based on C5 demonstrate that CMFD acceleration is quite efficient in reducing the number of MOC iterations and the computing time. It also shows that the larger scale of the problem, the better effect of the CMFD acceleration.