Based on the TSUNAMI-3D-K5 model of SCALE6.1 code, the complete 3d models of sphere bed high temperature gas cool experimental reactor HTR-10 and sphere bed model high temperature gas cool reactor HTR-PM core have been established to carry out the research of keffuncertainty by using the 44 groups covariance matrix of nuclear data built-in the SCALE6.1. Through the uncertainty and sensitivity analysis of different nuclear reactions in HTR-10 and HTR-PM, the mechanism of difference between the contributions of nuclear data to the keffuncertainty has been understood. The results show that the difference in neutron leakage due to the difference between the core sizes, the difference between material content of 239 Pu and 235 U and the average fission neutrons are the main reason for the difference between the contributions of nuclear data to the uncertainty of
keff.