2D/1D coupled method can obtain good accuracy and efficiency for 3D transport equation. Generally, parallel features of axial planes and MOC angles are adopted in many codes. However, large-scale parallel computation is not realized. In this paper, 2D/1D coupled whole-core transport method was studied within the framework of 3D CMFD, in which spacial domain-decomposed matrix MOC was radially adopted while finite difference diffusion was axially adopted. By combining the parallel features of both directions of the 2D/1D coupled method, the code Tiger-3D with large-scale parallel computation was developed based on MPI. Numerical results demonstrated that Tiger-3D has good accuracy and high efficiency.